Dual Effects of Curcuma longa Rhizome Powder Supplemented Diet on Lipid Profile of Indomethacin-Treated Albino Rats

Abstract

The effect of different percentages of Curcuma longa (C. longa) rhizome supplemented diet on lipid profile of indomethacin-induce ulcerated Wistar rat were investigated in this study. Thirty five (35) adult male Wistar rats of different weights 110 to 160g were randomly distributed into seven (7) Groups of five (5) rats each. Groups A-D (1- 5% groups) rats were placed on turmeric- supplemented diet of 1%, 2%, 5% and 10% respectively. Groups E, F and G (STD, NC and CTL group) were placed on basal diet and fed for 28 days. Thereafter, animals in all groups were fasted overnight and induced (except group G) with a single oral dose of indomethacin (60 mg/kg b.w.) and left for six (6) hours before sacrifice. Serum lipid profile (total cholesterol (TC), high density lipoprotein (HDL), triglycerides (TG) and low density lipoprotein (LDL-C) were determined. A significant (P<0.05) increased serum levels of TC, TG, LDL-C levels was observed in groups D and F animals when compared with group G. In addition, a significant diminution in HDL-C levels of animals in F and D groups in comparison with A-C groups were observed. However, there was a significant increased serum levels of HDL with a significant (P<0.05) decrease in serum total cholesterol, TG, LDL in groups A-C, E and G compared to groups D and E. This might be an indication that turmeric powder could mitigate the damaging effect of indomethacin and exhibit antihyperlipidemic potentials though in concentration dependent manner. Therefore, it could be a potential therapeutic agent for the treatment of dyslipidemia. Nonetheless, the increase in the serum levels of total cholesterol, TG, LDL and decrease in HDL could indicate that consumption of turmeric powder supplemented diet at 10% could enhance the damaging effects of indomethacin and that it could have hyperlipiemic properties. Therefore, it could be very detrimental to health at 10% concentration.